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Temporal Stability of Lipid-Shelled Microbubbles During Acoustically-Mediated Blood-Brain Barrier Opening by Pouliopoulos, Antonios N.; Jimenez, Daniella A.; Frank, Alexander; Robertson, Alexander; Zhang, Lin; Kline-Schoder, Alina R.; Bhaskar, Vividha; Harpale, Mitra; Caso, Elizabeth; Papapanou, Nicholas; Anderson, Rachel; Li, Rachel; Konofagou, Elisa E. is a Physics and Astronomy article available to read on EtoBox.
What is Temporal Stability of Lipid-Shelled Microbubbles During Acoustically-Mediated Blood-Brain Barrier Opening about?
Non-invasive blood-brain barrier (BBB) opening using focused ultrasound (FUS) is being tested as a means to locally deliver drugs into the brain. Such FUS therapies require injection of preformed microbubbles, currently used as contrast agents in ultrasound imaging. Although their behavior during exposure to imaging sequences has been well described, our understanding of microbubble stability within a therapeutic field is still not complete. Here, we study the temporal stability of lipid-shelled microbubbles during therapeutic FUS exposure in two timescales: the short time scale (i.e., μs of low-frequency ultrasound exposure) and the long time scale (i.e., days post-activation). We first simulated the microbubble response to low-frequency sonication, and found a strong correlation between viscosity and fragmentation pressure. Activated microbubbles had a concentration decay constant of 0.02 d^−1^ but maintained a quasi-stable size distribution for up to 3 weeks (< 10% variation). Microbubbles flowing through a 4-mm vessel within a tissue-mimicking phantom (5% gelatin) were exposed to therapeutic pulses (f~c~: 0.5 MHz, peak-negative pressure: 300 kPa, pulse length: 1 ms, pulse repet
Who reads Temporal Stability of Lipid-Shelled Microbubbles During Acoustically-Mediated Blood-Brain Barrier Opening?
It is typically read by researchers, students, and practitioners in Physics and Astronomy.
- Author
- Pouliopoulos, Antonios N.; Jimenez, Daniella A.; Frank, Alexander; Robertson, Alexander; Zhang, Lin; Kline-Schoder, Alina R.; Bhaskar, Vividha; Harpale, Mitra; Caso, Elizabeth; Papapanou, Nicholas; Anderson, Rachel; Li, Rachel; Konofagou, Elisa E.
- Publisher
- Frontiers Media SA; Frontiers Media S.A.; Lausanne: Frontiers Media S.A., 2013- (ISSN 2296-424X)
- Published
- 2020
- Language
- EN
- Field
- Physics and Astronomy (Physical Sciences)