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The Effects of Oxandrolone on the Growth Hormone and Gonadal Axes in Boys with Constitutional Delay of Growth and Puberty by A. Malhotra; E. Poon; W.‐Y. Tse; P. J. Pringle; P. C. Hindmarsh; C. G. D. Brook is a Medicine article available to read on EtoBox.

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## Summary OBJECTIVE We studied the effects of oxandrolone on serum concentrations of LH, FSH, testosterone, GH, SHBG, DHEAS, IGF‐I and insulin in boys with constitutional delay of growth and puberty. DESIGN Ten boys with constitutional delay of growth and puberty, mean age 138 years (range 12 4‐15‐5) were studied. Twenty‐four‐hour serum concentration profiles of GH, LH and FSH were constructed by drawing blood samples at 20‐minute intervals. Three study occasions over a period of 6 months were chosen to assess hormone concentrations before, during and 6 weeks after a 3‐month course of oxandrolone (2–5 mg once daily) therapy. RESULTS Growth velocity increased during oxandrolone treatment and stayed higher after therapy (pre 3.9 ± 0.5; on 6.3 ± 0.8; post 6.4 ± 0.9 cm/year (mean±SEM) two way ANOVA, __F__=5.3, __P__= 0.02). Oxandrolone had androgenic effects, suppressing mean serum LH concentrations from 1.7 ± 0.3 to 1.1 ± 0.2 U/I and serum testosterone concentrations from 1.9 ± 0.6 to 0.8 ± 0.1 nmol/l. SHBG concentrations were also reduced from 130.9 ± 14.6 to 307±73 nmol/l. Serum GH concentration fell slightly from 5.9 ± 0.6 to 4.8 ± 0.5 mU/l. After cessation of treatment, there was

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Author

A. Malhotra; E. Poon; W.‐Y. Tse; P. J. Pringle; P. C. Hindmarsh; C. G. D. Brook

Publisher

Wiley

Published

1993

Language

EN

Field

Medicine (Health Sciences)