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Dose dependency between cigarette consumption and reduced maternal serum PAPP‐A levels at 11–13^+6^ weeks of gestation by K. O. Kagan; V. Frisova; K. H. Nicolaides; K. Spencer is a Medicine article available to read on EtoBox.

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## Abstract ## Objective To examine whether in smokers there is a significant dose dependency between the number of cigarettes per day and levels of free __ß__‐hCG and pregnancy‐associated plasma protein A (PAPP‐A) at 11–13^+6^ weeks of gestation. ## Methods This was a retrospective analysis of the maternal serum free __ß__‐hCG and PAPP‐A levels in relation to the maternal smoking status in 109 263 chromosomally normal singleton pregnancies that had undergone first‐trimester screening for Down syndrome by a combination of fetal nuchal translucency thickness and maternal serum biochemistry. ## Results There were 95 287 nonsmokers and 13 976 cigarette smokers. The overall median PAPP‐A MoM among cigarette smokers was 0.827, which was 19.6% lower than the value of 1.029 in nonsmokers (__p__ < 0.0001 for log~10~ MoM). The respective values for β‐hCG MoM were 1.003 for smokers and 1.035 for nonsmokers (__p__ < 0.0001 for log~10~ MoM) which corresponds to a reduction of 3.1%. There was a significant inverse relationship between the number of cigarettes per day and the level of PAPP‐A MoM (__r__ = 0.989, __p__ < 0.0001) but not the level of free β‐hCG MoM (__r__ = 0.733; __p__ = 0.098). U

Who reads Dose dependency between cigarette consumption and reduced maternal serum PAPP‐A levels at 11–13^+6^ weeks of gestation?

Author

K. O. Kagan; V. Frisova; K. H. Nicolaides; K. Spencer

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 0197-3851)

Published

2007

Language

EN

Field

Medicine (Health Sciences)