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Can I read Expression of cytochrome P450 2A5 in preneoplastic and neoplastic mouse liver lesions on EtoBox?
Expression of cytochrome P450 2A5 in preneoplastic and neoplastic mouse liver lesions by Ute M. Wastl; Walter Rossmanith; Matti A. Lang; Anne-Marie Camus-Randon; Bettina Grasl-Kraupp; Wilfried Bursch; Rolf Schulte-Hermann is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Expression of cytochrome P450 2A5 in preneoplastic and neoplastic mouse liver lesions about?
Cytochrome P450 (CYP) 2A5 is involved in the metabolism of carcinogens like aflatoxin B1 and N-nitrosodiethylamine (NDEA), and CYP2A5 levels are increased in some pathological states of the liver (e.g., infectious hepatitis and porphyria). We analyzed the expression of CYP2A5 during experimental liver carcinogenesis in three different mouse strains (C3H/He, C57BL/6J, and B6C3F1) with immunohistochemical techniques and in situ hybridization. In normal liver, CYP2A5 protein and mRNA were detected in centrilobular hepatocytes only. Phenobarbital treatment increased the number of CYP2A5-positive centrilobular hepatocytes and the CYP2A5-positive areas were extended into the middle zone in all strains, but periportal hepatocytes remained negative. Fifty percent of the spontaneous foci in untreated mice, over 90% of the foci in mice treated with NDEA or phenobarbital and all of the hepatocellular adenomas and carcinomas displayed positive immunostaining and a strong CYP2A5 mRNA signal by in situ hybridization. In the liver tumors metastasized to the lung, expression of CYP2A5 had largely disappeared. CYP2A5 expression in neoplastic and putative preneoplastic lesions, although sometimes he
Who reads Expression of cytochrome P450 2A5 in preneoplastic and neoplastic mouse liver lesions?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Ute M. Wastl; Walter Rossmanith; Matti A. Lang; Anne-Marie Camus-Randon; Bettina Grasl-Kraupp; Wilfried Bursch; Rolf Schulte-Hermann
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0899-1987)
- Published
- 1998
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)