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Comparison of the characteristic of estrogenic action patterns of β-HCH and heregulin β1 in MCF-7 human breast cancer cells by Mariko Hatakeyama; Enmin Zou; Fumio Matsumura is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract In this study, we compared the estrogenic action pattern of β‐HCH to another ErbB2 activating agent, heregulin β1 (HRG), along with 17β‐estradiol and epidermal growth factor, to understand the similarities and differences of their action mechanisms. Not surprisingly, most of the initial test results indicated that the two agents, β‐HCH and HRG, are remarkably similar in several estrogenicity tests. However, in‐depth biochemical studies revealed that there are some distinct differences between these two compounds in affecting ErbB2 and ErbB3 at early stages of their action. Immunocoprecipitation and Western blot studies indicated that β‐HCH mainly promotes dimerization of ErbB2 and ErbB3 at early time points, whereas HRG causes their dimerization with a rapid and significant rise in their tyrosine phosphorylation levels. These results indicate that, while both β‐HCH and HRG act through ErbB2, their initial actions differ. To understand the long‐term consequence of such differential actions of these two agents, we tested the effect of a number of standard pathway specific inhibitors on their actions to induce foci formation after 2 weeks of exposure. The most conspicuous

Who reads Comparison of the characteristic of estrogenic action patterns of β-HCH and heregulin β1 in MCF-7 human breast cancer cells?

Author

Mariko Hatakeyama; Enmin Zou; Fumio Matsumura

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1095-6670)

Published

2002

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)