Can I read Effect Of Metabolic Inhibitors On Nuclear Pore Formation During The Hela S~3~ Cell Cycle on EtoBox?

Effect Of Metabolic Inhibitors On Nuclear Pore Formation During The Hela S~3~ Cell Cycle by Helmut M. Maul; Betty Yee Li Hsu; Thaddeus M. Borun; Gerd G. Maul is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Effect Of Metabolic Inhibitors On Nuclear Pore Formation During The Hela S~3~ Cell Cycle about?

The effect of various antimetabolites on nuclear pore formation was studied in synchronized HeLa S~3~ cells. The nuclear size was determined by light microscopy and the pore number per unit area of nuclear surface by the freeze-etching technique and electron microscopy. It was found that the inhibition of DNA replication or ribosomal RNA synthesis has no effect on nuclear size increase or pore formation. However, the inhibition of ATP synthesis effectively stops nuclear pore formation. Cycloheximide blocks nuclear pore formation at the same time during G~1~ phase of the cell cycle when nuclear size increase is blocked by high concentrations of actinomycin D. This suggests that certain proteins or other factors leading to pore formation and nuclear size increase are transcribed and synthesized at about 3–4 h after mitosis, i.e., about 1–2 h before S phase begins.

Who reads Effect Of Metabolic Inhibitors On Nuclear Pore Formation During The Hela S~3~ Cell Cycle?

Author

Helmut M. Maul; Betty Yee Li Hsu; Thaddeus M. Borun; Gerd G. Maul

Publisher

The Rockefeller University Press

Published

1973

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)