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A Prototype VP-PET Imaging System Based on Highly Pixelated CdZnTe Detectors by Yin, Yongzhi; Li, Yingguo; Wang, Tianguan; Huang, Chuan; Ye, Zhenqian; Li, Gongping is a Engineering article available to read on EtoBox.

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We investigated a prototype virtual-pinhole positron emission tomography (PET) system for small-animal imaging applications. The PET detector modules were made up of 1.3 mm lutetium-yttrium oxyorthosilicate (LYSO) arrays, and the insert detectors consisted of 0.6 mm pixelated cadmium zinc telluride (CdZnTe). To validate the imaging experiment, we did a Monte Carlo simulation for the virtual-pinhole PET (VP-PET) system in the Geant4 Application for Emission Tomography (GATE). For a point source of ^22^Na with a 0.5 mm diameter, the filtered back-projection algorithm-reconstructed PET image showed a resolution of 0.7 mm full-width-at-half-maximum. The system sensitivity was 0.46 cps/kBq at the center of the field view of the PET system with a source activity of 0.925 MBq and an energy window of 350 to 650 keV. A rod source phantom and a Derenzo phantom with ^18^F were also simulated to investigate the PET imaging ability. GATE simulation indicated that sources with 0.5 mm diameter could be clearly detected using 0.6 mm pixelated CdZnTe detectors as insert devices in a VP-PET system.

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Author

Yin, Yongzhi; Li, Yingguo; Wang, Tianguan; Huang, Chuan; Ye, Zhenqian; Li, Gongping

Publisher

Molecular Diversity Preservation International; MDPI AG; Multidisciplinary Digital Publishing Institute (MDPI); Basel: Molecular Diversity Preservation International (MDPI), 2001-; Publons (ISSN 1424-8220)

Published

2020

Language

EN

Field

Engineering (Physical Sciences)