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Can I read Synthesis and structure–Activity relationship studies of cinnamic acid-based novel thiazolidinedione antihyperglycemic agents on EtoBox?
Synthesis and structure–Activity relationship studies of cinnamic acid-based novel thiazolidinedione antihyperglycemic agents by Partha Neogi; Fredrick J Lakner; Satyanarayana Medicherla; Jin Cheng; Debendranath Dey; Maya Gowri; Bishwajit Nag; Somesh D Sharma; Lesley B Pickford; Coleman Gross is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Synthesis and structure–Activity relationship studies of cinnamic acid-based novel thiazolidinedione antihyperglycemic agents about?
A number of 2,4-thiazolidinedione derivatives of -phenyl substituted cinnamic acid were synthesized and studied for their PPAR agonist activity. The E-isomer of cinnamic acid, 11, showed moderate PPAR transactivation. The corresponding Z-isomer, 23, and double bond reduced derivative, 15, were found to be much less potent. Although the E-isomer showed a moderate PPARg transactivation, it demonstrated a strong glucose-lowering effect in a genetic rodent model of diabetes. Results of pharmacokinetic, metabolism and permeability studies are consistent with 11 being an active prodrug with an active metabolite, 14, that has similar glucose lowering and PPARg agonist properties.
Who reads Synthesis and structure–Activity relationship studies of cinnamic acid-based novel thiazolidinedione antihyperglycemic agents?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Partha Neogi; Fredrick J Lakner; Satyanarayana Medicherla; Jin Cheng; Debendranath Dey; Maya Gowri; Bishwajit Nag; Somesh D Sharma; Lesley B Pickford; Coleman Gross
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0968-0896)
- Published
- 2003
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)