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FAK Inhibitor-Based Combinations with MEK or PKC Inhibitors Trigger Synergistic Antitumor Effects in Uveal Melanoma by Malcy Tarin; Fariba Némati; Didier Decaudin; Christine Canbezdi; Benjamin Marande; Lisseth Silva; Héloïse Derrien; Aart G. Jochemsen; Sophie Gardrat; Sophie Piperno-Neumann; Manuel Rodrigues; Pascale Mariani; Nathalie Cassoux; Marc-Henri Stern; Sergio Roman-Roman; Samar Alsafadi is a Medicine article available to read on EtoBox.

What is FAK Inhibitor-Based Combinations with MEK or PKC Inhibitors Trigger Synergistic Antitumor Effects in Uveal Melanoma about?

## Simple Summary Uveal Melanoma (UM) is a rare and malignant intraocular tumor with dismal prognosis. Despite efficient control of the primary tumor by radiation or surgery, up to 50% of patients subsequently develop metastases, mainly in the liver. The treatment of UM metastases is challenging and the patient survival is very poor. Today, most of the tested treatments including inhibitors of protein kinase C (PKC), mitogen-activated protein kinase (MEK) or immune checkpoint blockade have been largely ineffective in patients with metastatic UM. Given that single-agent targeted therapies often activate compensatory mechanisms, combination strategies are relevant to evaluate in UM in preclinical and clinical settings. Our study confirms the previously described synergy of the dual inhibition of focal adhesion kinase (FAK) and MEK, and identifies a novel combination of drugs (FAK and PKC inhibitors) as a promising strategy for therapeutic intervention in metastatic UM. ## Abstract Uveal Melanoma (UM) is a rare and malignant intraocular tumor with dismal prognosis. Even if radiation or surgery permit an efficient control of the primary tumor, up to 50% of patients subsequently develop

Who reads FAK Inhibitor-Based Combinations with MEK or PKC Inhibitors Trigger Synergistic Antitumor Effects in Uveal Melanoma?

Author

Malcy Tarin; Fariba Némati; Didier Decaudin; Christine Canbezdi; Benjamin Marande; Lisseth Silva; Héloïse Derrien; Aart G. Jochemsen; Sophie Gardrat; Sophie Piperno-Neumann; Manuel Rodrigues; Pascale Mariani; Nathalie Cassoux; Marc-Henri Stern; Sergio Roman-Roman; Samar Alsafadi

Publisher

MDPI AG

Published

2023

Language

EN

Field

Medicine (Health Sciences)