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Predictive Value of Thyroxine for Prognosis in Pediatric Septic Shock: a Prospective Observational Study by Jia Song; Yun Cui; Chunxia Wang; Jiaying Dou; Huijie Miao; Xi Xiong; Yucai Zhang is a Medicine article available to read on EtoBox.

What is Predictive Value of Thyroxine for Prognosis in Pediatric Septic Shock: a Prospective Observational Study about?

Background: Thyroid hormone plays an important role in the adaptation of metabolic function to critically ill. The relationship between thyroid hormone levels and the outcomes of septic shock is still unclear. The aim of this study was to assess the predictive value of thyroid hormone for prognosis in pediatric septic shock. Methods: We performed a prospective observational study in a pediatric intensive care unit (PICU). Patients with septic shock were enrolled from August 2017 to July 2019. Clinical and laboratory indexes were collected, and thyroid hormone levels were measured on PICU admission. Results: Ninety-three patients who fulfilled the inclusion criteria were enrolled in this study. The incidence of nonthyroidal illness syndrome (NTIS) was 87.09% (81/93) in patients with septic shock. Multivariate logistic regression analysis showed that T4 level was independently associated with in-hospital mortality in patients with septic shock (OR: 0.965, 95% CI: 0.937-0.993, p = 0.017). The area under receiver operating characteristic (ROC) curve (AUC) for T4 was 0.762 (95% CI: 0.655-0.869). The cutoff threshold value of 58.71 nmol/L for T4 offered a sensitivity of 61.54% and a spec

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Author

Jia Song; Yun Cui; Chunxia Wang; Jiaying Dou; Huijie Miao; Xi Xiong; Yucai Zhang

Publisher

Walter de Gruyter GmbH

Published

2020

Language

EN

Field

Medicine (Health Sciences)