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Risk of Stroke in Older Adults With Heart Failure by Elizabeth Bierbower; Nayrana Griffith; Venkatesh K. Raman; Vijaywant Brar; Jeffrey Roseman; Prakash Deedwania; Gregg C. Fonarow; Richard M. Allman; Charles Faselis; Sijian Zhang; George Howard; Ali Ahmed; Phillip H. Lam is a Medicine article available to read on EtoBox.

What is Risk of Stroke in Older Adults With Heart Failure about?

Heart failure (HF) is a risk factor for incident stroke. However, less is known about the independent nature of this association and to what extent various baseline characteristics may mediate this risk. Of the 5,795 community-dwelling adults aged ≥65 years in the Cardiovascular Health Study, 5,448 were free of baseline stroke, of whom 229 had baseline HF. We used a multivariable-adjusted Cox regression model to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for centrally adjudicated incident stroke associated with HF. Participants had a mean age of 73 years, 58% were women, and 15% were African-American. During 23 years of follow-up, incident stroke occurred in 18.8% and 19.3% of those with and without HF, respectively, but the time to first stroke was shorter in those with HF (age-gender-race-adjusted HR 1.64, 95% CI 1.21 to 2.25). The association remained essentially unchanged after adjustments for tobacco, alcohol, and physical activity (HR 1.63, 95% CI 1.21 to 2.24), attenuated after adjustment for hypertension, atrial fibrillation, myocardial infarction, and diabetes mellitus (HR 1.26, 95% CI 0.92 to 1.72), and further attenuated after additional adjustment f

Who reads Risk of Stroke in Older Adults With Heart Failure?

Author

Elizabeth Bierbower; Nayrana Griffith; Venkatesh K. Raman; Vijaywant Brar; Jeffrey Roseman; Prakash Deedwania; Gregg C. Fonarow; Richard M. Allman; Charles Faselis; Sijian Zhang; George Howard; Ali Ahmed; Phillip H. Lam

Publisher

Elsevier BV

Published

2023

Language

EN

Field

Medicine (Health Sciences)