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20‐year trajectories of positive and negative symptoms after the first psychotic episode in patients with schizophrenia spectrum disorder: results from the OPUS study by Marie Starzer; Helene Gjervig Hansen; Carsten Hjorthøj; Nikolai Albert; Merete Nordentoft; Trine Madsen is a Psychology article available to read on EtoBox.

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This study aimed to identify the 20‐year trajectories of positive and negative symptoms after the first psychotic episode in a sample of patients with an ICD‐10 diagnosis of schizophrenia spectrum disorder, and to investigate the baseline characteristics and long‐term outcomes associated with these trajectories. A total of 373 participants in the OPUS trial were included in the study. Symptoms were assessed at baseline and after 1, 2, 5, 10 and 20 years using the Scales for the Assessment of Positive and Negative Symptoms. We used latent class growth mixture modelling to identify trajectories, and multinominal regression analyses to investigate predictors of membership to identified trajectories. Five trajectories of positive symptoms were identified: early continuous remission (50.9% of the sample), stable improvement (18.0%), intermittent symptoms (10.2%), relapse with moderate symptoms (11.9%), and continuous severe symptoms (9.1%). Substance use disorder (odds ratio, OR: 2.83, 95% CI: 1.09‐7.38, p=0.033), longer duration of untreated psychosis (OR: 1.02, 95% CI: 1.00‐1.03, p=0.007) and higher level of negative symptoms (OR: 1.60, 95% CI: 1.07‐2.39, p=0.021) were predictors of t

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Author

Marie Starzer; Helene Gjervig Hansen; Carsten Hjorthøj; Nikolai Albert; Merete Nordentoft; Trine Madsen

Publisher

Wiley

Published

2023

Language

EN

Field

Psychology (Social Sciences)