Can I read Evidence of a Limited Contribution of Feto–maternal Interactions to Trophoblast Differentiation Along the Invasive Pathway on EtoBox?

Evidence of a Limited Contribution of Feto–maternal Interactions to Trophoblast Differentiation Along the Invasive Pathway by F. Goffin; C. Munaut; A. Malassiné; D. Evain-Brion; F. Frankenne; V. Fridman; M. Dubois; S. Uzan; P. Merviel; J-M. Foidart is a Immunology and Microbiology article available to read on EtoBox.

What is Evidence of a Limited Contribution of Feto–maternal Interactions to Trophoblast Differentiation Along the Invasive Pathway about?

**Abstract:** Trophoblast differentiation is a key event in human placental development. During extravillous trophoblast (EVT) differentiation, stem cells from the anchoring villi detach from their basement membrane and proliferate to form aggregates called trophoblast cell columns (TCCs). They subsequently invade the decidua and differentiate into interstitial and endovascular trophoblasts. The influence of the decidua on EVT differentiation is controversial. We therefore compared the pattern of trophoblast differentiation marker expression in viable intrauterine and tubal pregnancies, as decidual cell markers (prolactin [PRL] and insulin‐like growth factor binding Protein‐1 [IGFBP1]) were only expressed in endometrial implantation sites. Extravillous trophoblast differentiation in anchoring villi from uterine and ectopic pregnancies exhibited a comparable phenotypical switch: α6 integrin subunit, E‐cadherin, EGF receptor, Ki 67 and connexin 40 were localized in the proximal part of the TCC, while α5β1 and α1 integrins, c‐erb B2, hPL and HLA‐G were expressed by invasive cytotrophoblasts. The cyclin‐dependent kinase inhibitors p16 and p57 were mainly detected in invasive cytotropho

Who reads Evidence of a Limited Contribution of Feto–maternal Interactions to Trophoblast Differentiation Along the Invasive Pathway?

Author

F. Goffin; C. Munaut; A. Malassiné; D. Evain-Brion; F. Frankenne; V. Fridman; M. Dubois; S. Uzan; P. Merviel; J-M. Foidart

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0001-2815)

Published

2003

Language

EN

Field

Immunology and Microbiology (Life Sciences)