Can I read Lobular Carcinoma In Situ of the Breast on EtoBox?
Lobular Carcinoma In Situ of the Breast by Eric R. Frykberg is a Medicine article available to read on EtoBox.
What is Lobular Carcinoma In Situ of the Breast about?
LCIS was first described in 1941 as a distinct pathologic entity by Foote and Stewart who called it a "rare form of mammary carcinoma." It is thought to represent a transitional intra-epithelial, or in situ, stage in the evolution of breast cancer from hyperplastic breast epithelium. With the wide application of mammography, its detection has increased in recent years, being found in approximately 1% of all breast biopsy specimens and 5% of all breast malignancies. Its true incidence is unknown, because the absence of any clinical or radiographic manifestations makes its detection completely arbitrary and random. LCIS has distinct pathologic features characterized by proliferation of bland, homogeneous malignant cells within the terminal duct-lobular apparatus. The lobular architecture and investing basement membrane remain intact with no evidence of invasion into the surrounding stoma. It is assumed to be widely disseminated throughout all breast tissue whenever it is found, having close to 100% incidence of multicentricity and bilaterality. The cells are typically of low histologic and nuclear grade, highly estrogen receptor positive, and have tumor marker characteristics of indo
Who reads Lobular Carcinoma In Situ of the Breast?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Eric R. Frykberg
- Publisher
- Hindawi Limited
- Published
- 1999
- Language
- EN
- Field
- Medicine (Health Sciences)