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Capillary electrophoresis–mass spectrometry: Recent trends in clinical proteomics by Claudia Desiderio; Diana Valeria Rossetti; Federica Iavarone; Irene Messana; Massimo Castagnola is a Chemistry article available to read on EtoBox.
What is Capillary electrophoresis–mass spectrometry: Recent trends in clinical proteomics about?
The increasing attention now paid to the elucidation of human proteome strengthened the development of analytical instruments able to provide reliable proteins and peptides quantitation and characterization in biological fluids and tissues. Emerging from proteomics, clinical proteomics exclusively considers its biomedical applications. It evaluates, often by high-throughput comparative platforms, the protein and peptide variations in body fluids, cells and tissues under different physiological and pathological conditions with the aim of discovering disease biomarkers. Among the available analytical methodologies, mass spectrometry in coupling with liquid chromatography or capillary electrophoresis demonstrated to be the eligible technique for protein detection and identification. This review summarizes the most recent applications of capillary electrophoresis-mass spectrometry to clinical proteomics, focusing on capillary zone electrophoresis separation mode and ESI and MALDI ionizations, which are the most frequently applied capillary electrophoresis-mass spectrometry hyphenated techniques.
Who reads Capillary electrophoresis–mass spectrometry: Recent trends in clinical proteomics?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Claudia Desiderio; Diana Valeria Rossetti; Federica Iavarone; Irene Messana; Massimo Castagnola
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0731-7085)
- Published
- 2010
- Language
- EN
- Field
- Chemistry (Physical Sciences)