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Cytokine Profiles in Human Immunodeficiency Virus-Infected Children Treated With Highly Active Antiretroviral Therapy by Brian M Jones; Susan SS Chiu; Wilfred HS Wong; Wilina WL Lim; Yu-lung Lau is a Medicine article available to read on EtoBox.

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## Context There have been few longitudinal studies of cytokine production in neonatally acquired HIV‐1 infection and none in Asian or Chinese children. ## Objective To determine whether monitoring cytokine production could contribute to the better management of pediatric patients with HIV‐1 infection. ## Setting Clinical Immunology Laboratory and Pediatrics Department, University Hospital, Hong Kong. ## Patients Ten Asian and 2 Eurasian children infected with HIV‐1 by mother‐to‐child transmission were followed for up to 5 years while on treatment with highly active antiretroviral therapy (HAART). ## Main Outcome Measures Numbers of unstimulated and mitogen‐activated cytokine‐secreting cells (IFN‐gamma, interleukin [IL]‐2, IL‐4, IL‐6, IL‐10, IL‐12, and TNF‐alpha) were measured by ELISPOT assay at frequent intervals, and correlations were sought with CD4+ and CD8+ cell counts and viral loads. ## Results Mitogen‐stimulated IL‐2‐secreting cells were directly associated with recovery of CD4+ cells. Correlations with viral load were found for Con A‐induced IFN‐gamma, Con A‐induced IL‐4, and unstimulated IL‐10, suggesting that these cytokines were either suppressed by high virus levels o

Who reads Cytokine Profiles in Human Immunodeficiency Virus-Infected Children Treated With Highly Active Antiretroviral Therapy?

Author

Brian M Jones; Susan SS Chiu; Wilfred HS Wong; Wilina WL Lim; Yu-lung Lau

Publisher

BioMed Central; Wiley (John Wiley & Sons); John Wiley and Sons Inc.; London: BioMed Central, 2008-2012; Geneva: International AIDS Society, 2012-; Wiley; Springer Science and Business Media LLC; International AIDS Society (ISSN 1758-2652)

Published

2005

Language

EN

ISBN

9781758265279

Field

Medicine (Health Sciences)