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Can I read Expression of cytotoxic molecules in intestinal T-cell lymphomas on EtoBox?
Expression of cytotoxic molecules in intestinal T-cell lymphomas by Severin Daum; Hans-Dieter Foss; Ioannis Anagnostopoulos; Bettina Dederke; Gudrun Demel; Iguaracyra Araujo; Ernst-Otto Riecken; Harald Stein; German Study Group on Intestinal non-Hodgkin Lymphoma is a Medicine article available to read on EtoBox.
What is Expression of cytotoxic molecules in intestinal T-cell lymphomas about?
Intestinal T-cell lymphoma (ITCL) represents a subgroup of peripheral T-cell lymphomas which is thought to arise from intraepithelial T-lymphocytes. Since these lymphocytes may contain cytotoxic molecules, the question of whether this also holds true for ITCL arises. Twenty ITCL cases were examined for the presence of granzyme B, perforin, and T-cell-restricted intracellular antigen (TIA-1)/granule membrane protein of 17 kD (GMP-17). Two molecules with restricted expression in cytotoxic cells, granzyme B and perforin, were detected by immunocytochemistry and by in situ hybridization with an isotopically labelled RNA probe, respectively. Immunocytochemistry was also performed with the antibody 2G9, which recognizes two molecules, one expressed by cytotoxic cells (TIA-1) and the other found in granulocytes and cytotoxic cells (GMP-17). Granzyme B, TIA-1/GMP-17, and perforin were found in the neoplastic cells of 16/19 cases, 19/20 cases, and 16/17 cases, respectively, of ITCL, but not in the tumour cells of the control group, which consisted of intestinal B-cell lymphomas (five cases) and CD8-negative peripheral nodal T-cell lymphomas (six cases). At least one of these molecules was e
Who reads Expression of cytotoxic molecules in intestinal T-cell lymphomas?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Severin Daum; Hans-Dieter Foss; Ioannis Anagnostopoulos; Bettina Dederke; Gudrun Demel; Iguaracyra Araujo; Ernst-Otto Riecken; Harald Stein; German Study Group on Intestinal non-Hodgkin Lymphoma
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0022-3417)
- Published
- 1997
- Language
- EN
- Field
- Medicine (Health Sciences)