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Can I read Quercetin Protects Against Acetaminophen-induced Hepatorenal Toxicity by Reducing Reactive Oxygen and Nitrogen Species on EtoBox?
Quercetin Protects Against Acetaminophen-induced Hepatorenal Toxicity by Reducing Reactive Oxygen and Nitrogen Species by Mostafa M. El-Shafey; Gamil M. Abd-Allah; Ahmed M. Mohamadin; Gamaleldin I. Harisa; Amr D. Mariee is a Medicine article available to read on EtoBox.
What is Quercetin Protects Against Acetaminophen-induced Hepatorenal Toxicity by Reducing Reactive Oxygen and Nitrogen Species about?
High or toxic doses of acetaminophen (APAP), a mild analgesic and antipyretic drug, can cause life-threatening hepatic and renal dysfunction. This study is designed to investigate the potential protective role of quercetin to attenuate the hepatorenal toxicity induced by a high single oral dose (3g/kg) of APAP in rats. Three main groups of Sprague-Dawley rats were used: quercetin, APAP and quercetin plus APAP-receiving animals. Corresponding control animals were also used. Interestingly, oral supplementation of quercetin (15mg/kg/day) prior to APAP intoxication dramatically reduced APAP-induced hepatorenal toxicity as evidenced by measuring serum lipid profile, total protein, urea, creatinine, ALT, AST, ALP, G-GT and liver tissue content of TC and TG. Quercetin treatment markedly prevented the generation of TBARS and PCC with substantial improvement in terms of GSH and activities of antioxidant enzymes in both liver and kidney homogenates. The relationship between quercetin and NO levels which is still a matter of debate, was also investigated. NO levels in serum, liver and kidney tissues were significantly inhibited in quercetin pre-treated animals. Furthermore, quercetin administ
Who reads Quercetin Protects Against Acetaminophen-induced Hepatorenal Toxicity by Reducing Reactive Oxygen and Nitrogen Species?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Mostafa M. El-Shafey; Gamil M. Abd-Allah; Ahmed M. Mohamadin; Gamaleldin I. Harisa; Amr D. Mariee
- Publisher
- Elsevier BV
- Published
- 2015
- Language
- EN
- Field
- Medicine (Health Sciences)