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Recent Advances in Amine Catalyzed Aldol Condensations by Bert Biesemans; Jeriffa De Clercq; Christian V. Stevens; Joris W. Thybaut; Jeroen Lauwaert is a Materials Science article available to read on EtoBox.

What is Recent Advances in Amine Catalyzed Aldol Condensations about?

During the past two decades, new insights have driven the development and optimization of aminated materials as aldol condensation catalysts. Amines, either primary or secondary, facilitate the reaction via an enamine mechanism. If the spatial placement with respect to the amine allows it, weak acid sites such as silanols or hydroxyls, can cooperate as hydrogen bond donors and aid in proton transfer steps. Furthermore, the reaction environment, i.e., support and solvent and their mutual interactions, is also a key determining factor. In particular, co-feeding small amounts of water suppresses the formation of inhibiting and site-blocking species. However, silica-based materials are susceptible to hydrolysis. This led to the development of water tolerant (bio)polymer supported amine catalysts which also exhibit selective component enrichment properties, opening up opportunities for further catalyst development.

Who reads Recent Advances in Amine Catalyzed Aldol Condensations?

Author

Bert Biesemans; Jeriffa De Clercq; Christian V. Stevens; Joris W. Thybaut; Jeroen Lauwaert

Publisher

Informa UK Limited

Published

2022

Language

EN

Field

Materials Science (Physical Sciences)