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Can I read Expression of MITF Gene in Melanogenesis with Psoralea corylifolia, Zingiber officinale, Terminalia chebula, Punica granatum and Eclipta alba Based on Poly-Herbal Formulation on EtoBox?
Expression of MITF Gene in Melanogenesis with Psoralea corylifolia, Zingiber officinale, Terminalia chebula, Punica granatum and Eclipta alba Based on Poly-Herbal Formulation by Shravan Kumar Ghali; Alokananda Chakraborty; Priyanka Pallapolu; Towseef Amin Rafeeqi; Gulam Mohammed Husain; Ghazala Javed; Mohammed Abdul Waheed; Munawwar Husain Kazmi is a Agricultural and Biological Sciences article available to read on EtoBox.
What is Expression of MITF Gene in Melanogenesis with Psoralea corylifolia, Zingiber officinale, Terminalia chebula, Punica granatum and Eclipta alba Based on Poly-Herbal Formulation about?
Pigmentation is an important physical characteristic of human beings due to the presence of a biopolymer molecule called melanin. Melanin pigment in the human skin and several other tissues were due to the activation and inhibition of different genes at the downstream signaling pathway like Tyrosinase-related protein 1 (TYRP1) and Tyrosinase-related protein 2 (TYRP2) and Microphthalmia-associated transcription factor (MITF) genes. In this study, we tried to deliver the molecular approach of TYRP1, TYRP2, and MITF by activating kinases in the process of Melanogenesis by treating with Unani formulations on the B16F10 murine melanoma cell line. RNA isolation of B16F10 cells was performed followed by cDNA conversion and expression studies at mRNA levels by RT-PCR method. To explore further western blot was performed at the protein level for the significant results which we obtained with UNIM regimes in the expression studies. The bioactive ingredient of UNIM-004 and UNIM-005 of Methanolic extracts up-regulates the expression and protein levels of the MITF gene which leads to the synthesis of melanin pigment in human beings. Therefore from this study, it indicates that the application a
Who reads Expression of MITF Gene in Melanogenesis with Psoralea corylifolia, Zingiber officinale, Terminalia chebula, Punica granatum and Eclipta alba Based on Poly-Herbal Formulation?
It is typically read by researchers, students, and practitioners in Agricultural and Biological Sciences.
- Author
- Shravan Kumar Ghali; Alokananda Chakraborty; Priyanka Pallapolu; Towseef Amin Rafeeqi; Gulam Mohammed Husain; Ghazala Javed; Mohammed Abdul Waheed; Munawwar Husain Kazmi
- Publisher
- Informa UK Limited
- Published
- 2021
- Language
- EN
- Field
- Agricultural and Biological Sciences (Life Sciences)