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T Helper‐Independent Activation of Human CD8^+^ Cells: the Role of CD28 Costimulation by S. W. VAN GOOL; YIQUN ZHANG; A. KASRAN; M. DE BOER; J. L. CEUPPENS is a Immunology and Microbiology article available to read on EtoBox.

What is T Helper‐Independent Activation of Human CD8^+^ Cells: the Role of CD28 Costimulation about?

The concept that activation of MHC class I‐restricted CD8^+^ cells entirely depends on help from MHC class II‐restricted CD4^+^ T cells has recently been supplemented with an alternative model in which CD8^+^ cells can directly be activated by MHC class I‐expressing professional antigen‐presenting cells (APC), which are able to deliver an accessory signal. The authors analysed the role of CD28‐mediated costimulation for T helper cell‐independent activation of purified human CD8^+^ T cells in two different __in vitro__ models. Freshly isolated CD8^+^ cells could be activated (proliferation, IL‐2 production and cytotoxic activity) by anti‐CD3‐presenting FcγR^+^ mouse cells transfected with the human CD28 ligand, CD80, as the only accessory signal. On the other hand, activation of CD8^+^ cells by allogeneic MHC class I on EBV‐transformed B cells, which express two different CD28 ligands, CD80 and CD86, also proceeded very efficiently (proliferation, cytotoxic activity and CD25 expression), but was either not, or only partially, blocked by anti‐CD80 and anti‐CD86 MoAb or CTLA‐4Ig. This indicates that other costimulatory signals are also effective, and that CD28 triggering is not absolu

Who reads T Helper‐Independent Activation of Human CD8^+^ Cells: the Role of CD28 Costimulation?

Author

S. W. VAN GOOL; YIQUN ZHANG; A. KASRAN; M. DE BOER; J. L. CEUPPENS

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0300-9475)

Published

1996

Language

EN

Field

Immunology and Microbiology (Life Sciences)