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Adaptative Biaryl Phosphite–Oxazole and Phosphite–Thiazole Ligands for Asymmetric Ir‐Catalyzed Hydrogenation of Alkenes by Javier Mazuela; Alexander Paptchikhine; Oscar Pàmies; Pher G. Andersson; Montserrat Diéguez is a Chemistry article available to read on EtoBox.
What is Adaptative Biaryl Phosphite–Oxazole and Phosphite–Thiazole Ligands for Asymmetric Ir‐Catalyzed Hydrogenation of Alkenes about?
## Abstract A library of readily available phosphite–oxazole/thiazole ligands (**L1 a**–**g**–**L7 a**–**g**) was applied in the Ir‐catalyzed asymmetric hydrogenation of several largely unfunctionalized __E__‐ and __Z__‐trisubstituted and 1,1‐disubstituted terminal alkenes. The ability of the catalysts to transfer chiral information to the product could be tuned by choosing suitable ligand components (bridge length, the substituents in the heterocyclic ring and the alkyl backbone chain, the configuration of the ligand backbone, and the substituents/configurations in the biaryl phosphite moiety), so that enantioselectivities could be maximized for each substrate as required. Enantioselectivities were therefore excellent (enantiomeric excess (__ee__) values up to >99 %) for a wide range of __E__‐ and __Z__‐trisubstituted and 1,1‐disubstituted terminal alkenes. The biaryl phosphite moiety was a very advantageous ligand component in terms of substrate versatility.
Who reads Adaptative Biaryl Phosphite–Oxazole and Phosphite–Thiazole Ligands for Asymmetric Ir‐Catalyzed Hydrogenation of Alkenes?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Javier Mazuela; Alexander Paptchikhine; Oscar Pàmies; Pher G. Andersson; Montserrat Diéguez
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Ltd.; Wiley (ISSN 0947-6539)
- Published
- 2010
- Language
- EN
- Field
- Chemistry (Physical Sciences)