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Differential multivariable risk prediction of appropriate shock versus competing mortality - A prospective cohort study to estimate benefits from ICD therapy by Leonard Bergau; Rik Willems; David J. Sprenkeler; Thomas H. Fischer; Panayota Flevari; Gerd Hasenfuß; Dimitrios Katsaras; Aleksandra Kirova; Stephan E. Lehnart; Lars Lüthje; Christian Röver; Joachim Seegers; Samuel Sossalla; Albert Dunnink; Rajevaa Sritharan; Anton E. Tuinenburg; Bert Vandenberk; Marc A. Vos; Sofieke C. Wijers; Tim Friede; Markus Zabel is a Medicine article available to read on EtoBox.

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## Background and objective: We prospectively investigated combinations of risk stratifiers including multiple ep diagnostics in a cohort study of icd patients. ## Methods: For 672 enrolled patients, we collected history, lvef, ep study and t-wave alternans testing, 24-h holter, nt-probnp, and the egfr. all-cause mortality and first appropriate icd shock were predefined endpoints. ## Results: The 635 patients included in the final analyses were 63 ± 13 years old, 81% were male, lvef averaged 40 ± 14%, 20% were inducible at ep study, 63% had a primary prophylactic icd. during follow-up over 4.3 ± 1.5 years, 108 patients died (4.0% per year), and appropriate shock therapy occurred in n = 96 (3.9% per year). in multivariate regression, age (p < 0.001), lvef (p < 0.001), nyha functional class (p = 0.007), egfr (p = 0.024), a history of atrial fibrillation (p = 0.011), and nt-pro-bnp (p = 0.002) were predictors of mortality. lvef (p = 0.002), inducibility at ep study (p = 0.007), and secondary prophylaxis (p = 0.002) were identified as independent predictors of appropriate shocks. a high annualized risk of shocks of about 10% per year was prevalent in the upper quintile of the shock sco

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Author

Leonard Bergau; Rik Willems; David J. Sprenkeler; Thomas H. Fischer; Panayota Flevari; Gerd Hasenfuß; Dimitrios Katsaras; Aleksandra Kirova; Stephan E. Lehnart; Lars Lüthje; Christian Röver; Joachim Seegers; Samuel Sossalla; Albert Dunnink; Rajevaa Sritharan; Anton E. Tuinenburg; Bert Vandenberk; Marc A. Vos; Sofieke C. Wijers; Tim Friede; Markus Zabel

Publisher

Elsevier Science; Elsevier ; Elsevier BV; Publons (ISSN 0167-5273)

Published

2018

Language

EN

Field

Medicine (Health Sciences)