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The Involvement of Matrix Metalloproteinase‐9 in Airway Inflammation of Patients with Acute Asthma by Y. C. Lee; H. B. Lee; Y. K. Rhee; C. H. Song is a Medicine article available to read on EtoBox.

What is The Involvement of Matrix Metalloproteinase‐9 in Airway Inflammation of Patients with Acute Asthma about?

**Background** Bronchial asthma is an inflammatory disease of the airway characterized by airway remodelling, and is due at least in part to an excess of extracellular matrix (ECM) deposition in the airway wall, which leads to subepithelial collagen deposition. Matrix metalloproteinase‐9 (MMP‐9) is the major proteolytic enzyme that induces bronchial remodelling in asthma. MMP‐9 is also important in the migration of inflammatory cells through basement membrane components. **Objectives** We evaluated whether airway inflammatory cells correlated with levels of MMP‐9 in acute asthma and we examined the time course of sputum levels of MMP‐9 activity in patients with spontaneous asthma exacerbation. **Methods** We performed zymographic analysis and checked levels of MMP‐9 by means of enzyme immunoassay. MMP‐9 levels were also evaluated during a spontaneous attack of asthma. **Results** Pro‐MMP‐9 activities and concentrations of MMP‐9 in asthmatic patients significantly exceeded those of control subjects (__P__ < 0.01). The activities of pro‐MMP‐9 were significantly higher in acute asthmatic patients than in stable asthmatic patients (__P__ < 0.01). The elevated MMP‐9 activities significa

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Author

Y. C. Lee; H. B. Lee; Y. K. Rhee; C. H. Song

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0954-7894)

Published

2001

Language

EN

Field

Medicine (Health Sciences)