Can I read Lithium protects against oxidative stress-mediated cell death in α-synuclein-overexpressing in vitro and in vivo models of Parkinson's disease on EtoBox?

Lithium protects against oxidative stress-mediated cell death in α-synuclein-overexpressing in vitro and in vivo models of Parkinson's disease by Yong-Hwan Kim; Anand Rane; Stephanie Lussier; Julie K. Andersen is a Neuroscience article available to read on EtoBox.

What is Lithium protects against oxidative stress-mediated cell death in α-synuclein-overexpressing in vitro and in vivo models of Parkinson's disease about?

## Abstract Lithium has recently been suggested to have neuroprotective properties in relation to several neurodegenerative diseases. In this study, we examined the potential cytoprotective effect of lithium in preventing oxidative stress‐induced protein accumulation and neuronal cell death in the presence of increased α‐synuclein levels in vitro and in vivo. Specifically, lithium administration was found to protect against cell death in a hydrogen peroxide‐treated, stable α‐synuclein‐enhanced green fluorescent protein (EGFP)‐overexpressing dopaminergic N27 cell line. Lithium feeding (0.255% lithium chloride) of 9‐month‐old pan‐neuronal α‐synuclein transgenic mice over a 3‐month period was also sufficient to prevent accumulation of oxidized/nitrated α‐synuclein as a consequence of chronic paraquat/maneb administration in multiple brain regions, including the glomerular layer, mitral cells, and the granule cell layer of the olfactory bulb (OB), striatum, substantia nigra pars compacta (SNpc) and Purkinje cells of the cerebellum. Lithium not only prevented α‐synuclein‐mediated protein accumulation/aggregation in these brain regions but also protected neuronal cells including mitral c

Who reads Lithium protects against oxidative stress-mediated cell death in α-synuclein-overexpressing in vitro and in vivo models of Parkinson's disease?

Author

Yong-Hwan Kim; Anand Rane; Stephanie Lussier; Julie K. Andersen

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0360-4012)

Published

2011

Language

EN

Field

Neuroscience (Life Sciences)