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Reliability of grading preoperative pancreatic neuroendocrine tumors on EUS specimens: a systematic review with meta-analysis of aggregate and individual data by Matteo Tacelli; Niccolò Bina; Stefano Francesco Crinò; Antonio Facciorusso; Ciro Celsa; Andrea Sbrozzi Vanni; Alberto Fantin; Filippo Antonini; Massimo Falconi; Fabio Monica; Gabriele Capurso; Paolo Giorgio Arcidiacono; Luca Barresi is a Medicine article available to read on EtoBox.

What is Reliability of grading preoperative pancreatic neuroendocrine tumors on EUS specimens: a systematic review with meta-analysis of aggregate and individual data about?

## Background and aims: Therapy and prognosis of pancreatic neuroendocrine tumors (pannets) are strictly related to the ki-67 index, which defines tumor grading. the criterion standard for the assessment of grading of pannets is eus-guided fna (eus-fbafna) or eus-guided fine-needle biopsy sampling (eus-fnb). because data on diagnostic accuracy of eus-fna and eus-fnb are heterogeneous, we aimed to analyze the variability in concordance between eus grading and surgical grading. ## Methods: The medline, scopus, and embase databases were searched until november 2021 to identify studies reporting the concordance rate between eus grading and surgical grading. the study was conducted in accordance with preferred reporting items for systematic reviews and meta-analyses guidelines. pooled events were calculated using a random-effects model and expressed in terms of pooled prevalence rates. a multivariate meta-regression was performed to find possible sources of heterogeneity. where available, individual data were analyzed. ## Results: Twenty-six studies with 864 patients undergone eus-fna or eus-fnb and surgical resection for pannets were included. the pooled estimate rate for the overall c

Who reads Reliability of grading preoperative pancreatic neuroendocrine tumors on EUS specimens: a systematic review with meta-analysis of aggregate and individual data?

Author

Matteo Tacelli; Niccolò Bina; Stefano Francesco Crinò; Antonio Facciorusso; Ciro Celsa; Andrea Sbrozzi Vanni; Alberto Fantin; Filippo Antonini; Massimo Falconi; Fabio Monica; Gabriele Capurso; Paolo Giorgio Arcidiacono; Luca Barresi

Publisher

Elsevier BV

Published

2022

Language

EN

Field

Medicine (Health Sciences)