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Can I read Sulpiride‐induced Hyperprolactinaemia Increases Retinal Vasoinhibin and Protects Against Diabetic Retinopathy in Rats on EtoBox?
Sulpiride‐induced Hyperprolactinaemia Increases Retinal Vasoinhibin and Protects Against Diabetic Retinopathy in Rats by Elva Adán‐Castro; Lourdes Siqueiros‐Márquez; Gabriela Ramírez‐Hernández; Nundehui Díaz‐Lezama; Xarubet Ruíz‐Herrera; Francisco Freinet Núñez; Carlos D. Núñez‐Amaro; Ma. Ludivina Robles‐Osorio; Thomas Bertsch; Jakob Triebel; Gonzalo Martínez de la Escalera; Carmen Clapp is a Neuroscience article available to read on EtoBox.
What is Sulpiride‐induced Hyperprolactinaemia Increases Retinal Vasoinhibin and Protects Against Diabetic Retinopathy in Rats about?
## Abstract Excessive vasopermeability and angiogenesis compromise vision in diabetic macular oedema (DME) and diabetic retinopathy (DR). Vasoinhibin is a fragment of the hormone prolactin (PRL) that inhibits diabetes‐induced retinal hypervasopermeability and ischaemia‐induced retinal angiogenesis in rodents. Hyperprolactinaemia generated by the dopamine D2 receptor antagonist, levosulpiride, is associated with higher levels of vasoinhibin in the vitreous of patients with DR, implying a beneficial outcome due to vasoinhibin‐mediated inhibition of retinal vascular alterations. Here, we tested whether hyperprolactinaemia induced by racemic sulpiride increases intraocular vasoinhibin levels and inhibits retinal hypervasopermeability in diabetic rats. Diabetes was generated with streptozotocin and, 4 weeks later, rats were treated for 2 weeks with sulpiride or osmotic minipumps delivering PRL. ELISA, Western blot, and Evans blue assay were used to evaluate serum PRL, retinal vasoinhibin, and retinal vasopermeability, respectively. Hyperprolactinaemia in response to sulpiride or exogenous PRL was associated with increased levels of vasoinhibin in the retina and reduced retinal hypervaso
Who reads Sulpiride‐induced Hyperprolactinaemia Increases Retinal Vasoinhibin and Protects Against Diabetic Retinopathy in Rats?
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- Author
- Elva Adán‐Castro; Lourdes Siqueiros‐Márquez; Gabriela Ramírez‐Hernández; Nundehui Díaz‐Lezama; Xarubet Ruíz‐Herrera; Francisco Freinet Núñez; Carlos D. Núñez‐Amaro; Ma. Ludivina Robles‐Osorio; Thomas Bertsch; Jakob Triebel; Gonzalo Martínez de la Escalera; Carmen Clapp
- Publisher
- Wiley
- Published
- 2022
- Language
- EN
- Field
- Neuroscience (Life Sciences)