About this Medicine article
Allergen-specific conventional immunotherapy decreases immunoglobulin E-mediated basophil histamine releasability by J.-Y. Shim; B.-S. Kim; S.-H. Cho; K.-U. Min; S.-J. Hong is a Medicine article available to read on EtoBox.
## Summary **Background** Allergen‐specific immunotherapy has proven to be clinically effective in the treatment of patients with atopic asthma; however, the mechanisms are still unclear. Several noted immunological changes include an increase of the allergen‐specific IgG antibody, a reduction in the allergen‐specific IgE antibody subsequent to transient increase, an allergen‐specific T cell shift in cytokine production from Th2 to Th1, and a decrease in quantity and activity of basophils and mast cells. **Objective** To analyse the changes of basophil histamine release in response to IgE‐mediated and non‐IgE‐mediated stimuli before and after conventional house‐dust mite immunotherapy in children who suffer from atopic asthma. **Methods** Fourteen __Dermatophagoides farinae__ (__Df__) sensitive asthmatic children with conventional immunotherapy were examined. Basophil histamine releasability was measured 0 months (just before immunotherapy), 4 months and 9 months after immunotherapy. Basophils were stimulated with __Df__ and goat anti‐human IgE antibody as IgE‐mediated stimuli; and formyl‐Met‐Leu‐Phe (fMLP) and calcium ionophore A23187 as non‐IgE‐mediated stimuli. Accordingly, the
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- Author
- J.-Y. Shim; B.-S. Kim; S.-H. Cho; K.-U. Min; S.-J. Hong
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0954-7894)
- Published
- 2003
- Language
- EN
- Field
- Medicine (Health Sciences)