Can I read Ionically Cross-linked Alginate-chitosan Core-shell Hydrogel Beads for Oral Delivery of Insulin on EtoBox?

Ionically Cross-linked Alginate-chitosan Core-shell Hydrogel Beads for Oral Delivery of Insulin by V.H. Giang Phan; Ramya Mathiyalagan; Minh-Thu Nguyen; Thanh-Tuyen Tran; Mohanapriya Murugesan; Tuyet-Nhung Ho; Ha Huong; Deok Chun Yang; Yi Li; Thavasyappan Thambi is a Materials Science article available to read on EtoBox.

What is Ionically Cross-linked Alginate-chitosan Core-shell Hydrogel Beads for Oral Delivery of Insulin about?

Here, core-shell hydrogel beads for oral insulin delivery at intestine was reported, which was a target site for insulin absorption. The core-shell hydrogel beads were prepared using naturally derived alginate and chitosan polysaccharides by simple dropping technique. In order to effectively control leakage of insulin from core-shell hydrogel beads, insulin was embedded into the layered double hydroxides (LDHs). LDH/insulin-loaded complexes were firstly coated with chitosan, and then coated with alginate to generate core-shell hydrogel beads. The biocompatibility and angiogenic response of core-shell hydrogel beads were evaluated by direct contact of the beads with chick embryo chorioallantoic membrane, which indicates safety of the core-shell beads. The beads successfully retained the insulin within the core-shell structure at pH 1.2, indicating that insulin had a good protective effect in harsh acidic environments. Interestingly, insulin release starts at the simulated intestinal fluid (pH 6.8) and continue to release for 24 h in a sustained manner.

Who reads Ionically Cross-linked Alginate-chitosan Core-shell Hydrogel Beads for Oral Delivery of Insulin?

Author

V.H. Giang Phan; Ramya Mathiyalagan; Minh-Thu Nguyen; Thanh-Tuyen Tran; Mohanapriya Murugesan; Tuyet-Nhung Ho; Ha Huong; Deok Chun Yang; Yi Li; Thavasyappan Thambi

Publisher

Elsevier BV

Published

2022

Language

EN

Field

Materials Science (Physical Sciences)