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Tumor‐Specific Peroxynitrite Overproduction Disrupts Metabolic Homeostasis for Sensitizing Melanoma Immunotherapy by Lijun Yang; Dianyu Wang; Haixue Jia; Cuihong Yang; Yumin Zhang; Hui Li; Jinjian Liu; Jianfeng Liu is a Engineering article available to read on EtoBox.
What is Tumor‐Specific Peroxynitrite Overproduction Disrupts Metabolic Homeostasis for Sensitizing Melanoma Immunotherapy about?
## Abstract Tumor cells elicit metabolic reprogramming to establish an immunosuppressive tumor microenvironment (TME) for escaping from immunosurveillance. Therefore, interrupting the metabolic adaptation of tumor cells may be a promising strategy for TME immunomodulation, favoring immunotherapy. In this work, a tumor‐specific peroxynitrite nanogenerator APAP‐P‐NO is constructed that can selectively disrupt metabolic homeostasis in melanoma cells. Stimulated by melanoma‐characteristic acid, glutathione, and tyrosinase, APAP‐P‐NO can efficiently generate peroxynitrite through the in situ coupling of the produced superoxide anion and released nitric oxide. Metabolomics profiling reveals that the accumulated peroxynitrite induces a great decrease in metabolites in the tricarboxylic acid cycle. Meanwhile, the glycolysis‐produced lactate drops sharply both intracellularly and extracellularly under peroxynitrite stress. Mechanistically, peroxynitrite impairs the activity of glyceraldehyde‐3‐phosphate dehydrogenase in glucose metabolism through S‐nitrosylation. The metabolic alterations effectively reverse the immunosuppressive TME to evoke potent antitumor immune responses, including pol
Who reads Tumor‐Specific Peroxynitrite Overproduction Disrupts Metabolic Homeostasis for Sensitizing Melanoma Immunotherapy?
It is typically read by researchers, students, and practitioners in Engineering.
- Author
- Lijun Yang; Dianyu Wang; Haixue Jia; Cuihong Yang; Yumin Zhang; Hui Li; Jinjian Liu; Jianfeng Liu
- Publisher
- Wiley
- Published
- 2023
- Language
- EN
- Field
- Engineering (Physical Sciences)