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What is G6PD Deficiency: Genetic Polymorphism Insights about?

G6PD deficiency is a well-studied example of genetic variation and balanced polymorphism, located on the X chromosome and crucial for protecting red blood cells from oxidative stress. Over 230 variants exist, with specific geographic distributions influenced by malaria selection, providing a survival advantage despite the risk of hemolysis. Recent analyses reveal that G6PD polymorphism represents a continuous spectrum of enzyme activity rather than distinct categories, highlighting the complex interplay of

Author

aronnomusix

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EN