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Breast-Conserving Treatment With Partial or Whole Breast Irradiation for Low-Risk Invasive Breast Carcinoma—5-Year Results of a Randomized Trial by Csaba Polgár; János Fodor; Tibor Major; György Németh; Katalin Lövey; Zsolt Orosz; Zoltán Sulyok; Zoltán Takácsi-Nagy; Miklós Kásler is a Medicine article available to read on EtoBox.

What is Breast-Conserving Treatment With Partial or Whole Breast Irradiation for Low-Risk Invasive Breast Carcinoma—5-Year Results of a Randomized Trial about?

## Purpose: To report the 5-year results of a randomized study comparing the survival and cosmetic results of breast-conserving treatment with partial breast irradiation (pbi) or conventional whole breast irradiation (wbi). ## Methods and materials: Between 1998 and 2004, 258 selected patients with t1 n0-1mi, grade 1-2, nonlobular breast cancer without presence of extensive intraductal component and resected with negative margins were randomized after breast-conserving surgery to receive 50 gy/25 fractions wbi (n = 130) or pbi (n = 128). the latter consisted of either 7 x 5.2 gy high-dose-rate (hdr) multicatheter brachytherapy (bt; n = 88) or 50 gy/25 fractions electron beam (eb) irradiation (n = 40). ## Results: At a median follow-up of 66 months, the 5-year actuarial rate of local recurrence was 4.7% and 3.4% in the pbi and wbi arms, respectively (p = 0.50). there was no significant difference in the 5-year probability of overall survival (94.6% vs. 91.8%), cancer-specific survival (98.3% vs. 96.0%), and disease-free survival (88.3% vs. 90.3%). the rate of excellent to good cosmetic result was 77.6% in the pbi group (81.2% after hdr bt; 70.0% after eb) and 62.9% in the control gr

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Author

Csaba Polgár; János Fodor; Tibor Major; György Németh; Katalin Lövey; Zsolt Orosz; Zoltán Sulyok; Zoltán Takácsi-Nagy; Miklós Kásler

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)

Published

2007

Language

EN

Field

Medicine (Health Sciences)