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A Photoacoustic Finder Fully Integrated with a Solid-state Dye Laser and Transparent Ultrasound Transducer by Park, Byullee (author);Han, Moongyu (author);Park, Jeongwoo (author);Kim, Taejeong (author);Ryu, Hanyoung (author);Seo, Youngseok (author);Kim, Won Jong (author);Kim, Hyung Ham (author);Kim, Chulhong (author) is a Engineering article available to read on EtoBox.

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The standard-of-care for evaluating lymph node status in breast cancers and melanoma metastasis is sentinel lymph node (SLN) assessment performed with a handheld gamma probe and radioisotopes. However, this method inevitably exposes patients and physicians to radiation, and the special facilities required limit its accessibility. Here, we demonstrate a non-ionizing, cost-effective, handheld photoacoustic finder (PAF) fully integrated with a solid-state dye laser and transparent ultrasound transducer (TUT). The solid-state dye laser handpiece is coaxially aligned with the spherically focused TUT. The integrated finder readily detected photoacoustic signals from a tube filled with methylene blue (MB) beneath a 22 mm thick layer of chicken tissue. In live animals, we also photoacoustically detected both SLNs injected with MB and subcutaneously injected melanomas. We believe that our radiation-free and inexpensive PAF can play a vital role in SLN assessment.

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Author

Park, Byullee (author);Han, Moongyu (author);Park, Jeongwoo (author);Kim, Taejeong (author);Ryu, Hanyoung (author);Seo, Youngseok (author);Kim, Won Jong (author);Kim, Hyung Ham (author);Kim, Chulhong (author)

Publisher

Elsevier BV

Published

2021

Language

EN

Field

Engineering (Physical Sciences)