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Can I read Tracking HIV Rebound following Latency Reversal Using Barcoded HIV on EtoBox?
Tracking HIV Rebound following Latency Reversal Using Barcoded HIV by Marsden, Matthew D. ;Zhang, Tian-hao ;Du, Yushen ;Dimapasoc, Melanie ;Soliman, Mohamed S.A. ;Wu, Xiaomeng ;Kim, Jocelyn T. ;Shimizu, Akira ;Schrier, Adam ;Wender, Paul A. ;Sun, Ren ;Zack, Jerome A. is a Medicine article available to read on EtoBox.
What is Tracking HIV Rebound following Latency Reversal Using Barcoded HIV about?
## Summary HIV latency prevents cure of infection with antiretroviral therapy (ART) alone. One strategy for eliminating latently infected cells involves the induction of viral protein expression via latency-reversing agents (LRAs), allowing killing of host cells by viral cytopathic effects or immune effector mechanisms. Here, we combine a barcoded HIV approach and a humanized mouse model to study the effects of a designed, synthetic protein kinase C modulating LRA on HIV rebound. We show that administration of this compound during ART results in a delay in rebound once ART is stopped. Furthermore, the rebounding virus appears composed of a smaller number of unique barcoded viruses than occurs in control-treated animals, suggesting that some reservoir cells that would have contributed virus to the rebound process are eliminated by LRA administration. These data support the use of barcoded virus to study rebound and suggest that LRAs may be useful in HIV cure efforts.
Who reads Tracking HIV Rebound following Latency Reversal Using Barcoded HIV?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Marsden, Matthew D. ;Zhang, Tian-hao ;Du, Yushen ;Dimapasoc, Melanie ;Soliman, Mohamed S.A. ;Wu, Xiaomeng ;Kim, Jocelyn T. ;Shimizu, Akira ;Schrier, Adam ;Wender, Paul A. ;Sun, Ren ;Zack, Jerome A.
- Publisher
- Elsevier BV
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)