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Extended-spectrum beta-lactamase Escherichia coli and Klebsiella pneumoniae urinary tract infections by P. Vachvanichsanong; E. B. McNeil; P. Dissaneewate is a Medicine article available to read on EtoBox.

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The prevalence of extended**-**spectrum beta**-**lactamase (ESBL)-producing __Escherichia coli__ and __Klebsiella pneumoniae__ urinary tract infections (UTIs) is increasing worldwide. We investigated the prevalence, clinical findings, impact and risk factors of ESBL __E. coli__/__K. pneumoniae__ UTI through a retrospective review of the medical records of children with UTI aged <15 years admitted to Prince of Songkla University Hospital, Thailand over 10 years (2004–2013). Thirty-seven boys and 46 girls had ESBL-positive isolates in 102 UTI episodes, compared with 85 boys and 103 girls with non-ESBL isolates in 222 UTI episodes. The age of presentation and gender were not significantly different between the two groups. The prevalence of ESBL rose between 2004 and 2008 before plateauing at around 30–40% per year, with a significant difference between first and recurrent UTI episodes of 27.3% and 46.5%, respectively (__P__ = 0.003). Fever prior to UTI diagnosis was found in 78.4% of episodes in the non-ESBL group and 61.8% of episodes in the ESBL group (__P__ = 0.003). Multivariate analysis indicated that children without fever (odds ratio (OR) 2.14, 95% confidence interval (CI) 1.23

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Author

P. Vachvanichsanong; E. B. McNeil; P. Dissaneewate

Publisher

Cambridge University Press (CUP)

Published

2020

Language

EN

Field

Medicine (Health Sciences)