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Can I read Hippocampal Transcriptional Dysregulation After Renal Ischemia and Reperfusion on EtoBox?
Hippocampal Transcriptional Dysregulation After Renal Ischemia and Reperfusion by An-Hsun Chou; Chiou-Mei Lee; Chun-Yu Chen; Jiin-Tarng Liou; Fu-Chao Liu; Ying-Ling Chen; Yuan-Ji Day is a Neuroscience article available to read on EtoBox.
What is Hippocampal Transcriptional Dysregulation After Renal Ischemia and Reperfusion about?
Neurological complications contribute largely to the morbidity and mortality in patients with acute renal failure. In order to study pathophysiological complications of renal failure, a murine model of renal ischemia/reperfusion-induced acute kidney injury (AKI) was generated by 60min bilateral ischemia, and followed by 2h or 24h reperfusion (B-60'IRI). Compared to the sham-operated mice, B-60'IRI mice exhibited a significant inflammatory injury to remote brain. We found that serum and brain levels of KC, G-CSF and MCP-1 were significantly increased in B-60'IRI mice after 2h and 24h reperfusion when compared with sham-operated mice. Moreover, B-60'IRI mice exhibited increased numbers of activated microglial cells in the brain, and severe blood-brain barrier (BBB) permeability when compared with the control sham mice. The technology of cDNA microarray and quantitated RT-PCR are used to identify hippocampal genes whose expression is altered in response to AKI in B-60' IRI mice. The initiation of transcriptional abnormality was indicated by the finding that B-60' IRI mice exhibited upregulated mRNA levels of genes involved in inflammation, cell signaling, extracellular matrix and cell
Who reads Hippocampal Transcriptional Dysregulation After Renal Ischemia and Reperfusion?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- An-Hsun Chou; Chiou-Mei Lee; Chun-Yu Chen; Jiin-Tarng Liou; Fu-Chao Liu; Ying-Ling Chen; Yuan-Ji Day
- Publisher
- Elsevier BV
- Published
- 2014
- Language
- EN
- Field
- Neuroscience (Life Sciences)