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Glomeruloid hemangioma in POEMS syndrome shows two different immunophenotypic endothelial cells by Saburo Kishimoto; Hideya Takenaka; Ryo Shibagaki; Yosuke Noda; Mari Yamamoto; Hirokazu Yasuno is a Medicine article available to read on EtoBox.
What is Glomeruloid hemangioma in POEMS syndrome shows two different immunophenotypic endothelial cells about?
The case of a Japanese woman with glomeruloid hemangioma, an initial marker for POEMS syndrome, is reported. Her cutaneous lesions were multiple and consisted of glomeruloid hemangiomas, cherry‐type capillary hemangiomas, and a mixture of both. The specimens of glomeruloid hemangiomas were studied by paraffin section immunohistochemistry with a large panel of antibodies and electron microscopy, respectively. The lesions, whose size ranged from minute foci to large nodules, were composed of anastomosing vascular channels resembling renal glomeruli and had irregular lumina, often featuring capillaries and sinusoid‐like spaces. The vascular channels were lined by a single layer of endothelial cells, which showed two types of cells. The capillary‐type endothelium possessed large vesicular nuclei with open chromatin and large amount of cytoplasm. The sinusoidal endothelium possessed small basal nuclei with dense chromatin as well as scant amount of cytoplasm. The former cells had a characteristic CD31^+^/CD34^+^/UEA I ^+^/CD68^−^ phenotype. Some of these cells ultrastructurally showed intracytoplasmic lumen formation. The latter cells had a characteristic CD31^+^/CD34^−^/UEA I^−^/CD68^+
Who reads Glomeruloid hemangioma in POEMS syndrome shows two different immunophenotypic endothelial cells?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Saburo Kishimoto; Hideya Takenaka; Ryo Shibagaki; Yosuke Noda; Mari Yamamoto; Hirokazu Yasuno
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0303-6987)
- Published
- 2000
- Language
- EN
- Field
- Medicine (Health Sciences)