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CONTENTS 6 Cover 1 Title 2 Copyright 3 End User License Agreement 4 Contents 6 Preface 9 List of Contributors 10 PI3K/Akt/mTOR Pathway in Acute Lymphoblastic Leukemia Targeted Therapies 12 Carolina Simioni1, Giorgio Zauli2,3, Daniela Milani2 and Luca M. Neri2,4,* 12 INTRODUCTION 12 Acute Lymphoblastic Leukemia 14 PI3K/Akt/mTOR Signaling 16 Aberrant PI3K/Akt/mTOR Expression in ALL 18 PI3K Inhibition in ALL 19 Akt Inhibition 21 Classes of mTOR Inhibitors: Roles of Rapamycin, Rapalogs, Dual PI3K/mTOR Inhibitors and TORKIs 23 Clinical Trials 30 PI3K Inhibition 30 Akt Inhibition 31 mTOR Inhibition 31 CONCLUDING REMARKS 32 LIST OF ABBREVIATIONS 33 CONSENT FOR PUBLICATION 34 CONFLICT OF INTEREST 34 ACKNOWLEDGEMENTS 34 REFERENCES 34 Polymeric Nanomedicines in Treatment of Breast Cancer: Review of Contemporary Research 47 Farooq Ali Khan1,#, Md. Rizwanullah2,#, Ahmad Perwez3, Mohammad Zaki Ahmad4 and Javed Ahmad4,* 47 INTRODUCTION 48 CHALLENGES IN TREATMENT OF BREAST CANCER 48 POTENTIAL OF POLYMERIC NANOMEDICINES IN TREATMENT OF BREAST CANCER 50 TARGETING IN TREATMENT OF BREAST CANCER 52 Passive Targeting 52 Active Targeting 53 DIFFERENT POLYMERIC NANOMEDICINES IN TREATMENT OF BREAST CAN
- Author
- Atta ur-Rahman;Muhammad Iqbal Choudhary;
- Language
- EN
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