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Analysis of aromatic DNA adducts and 7,8-dihydro-8-oxo- 2′-deoxyguanosine in lymphocyte DNA from a case–control study of lung cancer involving minority populations by Suryanarayana V. Vulimiri; Xifeng Wu; Wanda Baer-Dubowska; Mariza de Andrade; Michelle Detry; Margaret R. Spitz; John DiGiovanni is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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The purpose of this study was to examine the level of smoking-related aromatic DNA adducts and oxidative DNA damage in current smokers from a lung cancer case-control study in African Americans and Mexican Americans. In addition, mutagen sensitivity (bleomycin-induced chromatid breaks), a marker of genetic susceptibility, was assessed in these patients and correlated with the level of DNA damage. Lymphocyte DNA from cases and age-, sex-, and ethnicity-matched controls was analyzed for aromatic DNA adducts (43 cases and 47 controls) and the level of 7,8dihydro-8-oxo-2 H -deoxyguanosine (8-oxo-dG) was determined in 46 cases and 48 controls using 32 P-postlabeling. Overall, lung cancer cases had significantly (P `0.05) higher levels of aromatic DNA adducts and 8-oxo-dG (mean AE SEM; 6.03 AE 1.16/10 8 nucleotides and 5.82 AE 0.77/10 5 nucleotides, respectively) compared to the controls (2.80 AE 0.36/10 8 nucleotides and 3.65 AE 0.56/10 5 nucleotides, respectively). The case-control differences for these two biomarkers were especially evident in current smokers. Both male and female lung cancer cases had higher levels of aromatic DNA adducts compared to the corresponding controls but on

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Author

Suryanarayana V. Vulimiri; Xifeng Wu; Wanda Baer-Dubowska; Mariza de Andrade; Michelle Detry; Margaret R. Spitz; John DiGiovanni

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0899-1987)

Published

2000

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)