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Can I read A Dual-functional Chitosan Derivative Platform for Fungal Keratitis on EtoBox?
A Dual-functional Chitosan Derivative Platform for Fungal Keratitis by Liuqi Shi; Zhanrong Li; Zhen Liang; Junjie Zhang; Ruixing Liu; Dandan Chu; Lei Han; Lei Zhu; Jianliang Shen; Jingguo Li is a Materials Science article available to read on EtoBox.
What is A Dual-functional Chitosan Derivative Platform for Fungal Keratitis about?
Fungal keratitis remains a serious infectious ocular disease, and the traditional administration of eye drops is limited by ocular intrinsic barriers and drug shortages. Herein, we fabricated a chitosan-based dual-functional platform for ocular topical delivery of econazole. The platform can prolong the residence time on the ocular surface due to its strong interaction with the mucin layer by physical adhesion and covalent bonding, and also open corneal epithelial tight junctions for being positively charged, thereby enhancing corneal penetration of drug. Using these strategies, dosing concentration was reduced from 0.3 wt% to 0.1 wt%, dosing frequency was reduced from once-an-hour to twice-daily, in vitro and in vivo antifungal therapeutic effects were achieved and patient compliance could be improved. Given its high structural adaptability, many other ocular anterior segment-related diseases would benefit from this platform.
Who reads A Dual-functional Chitosan Derivative Platform for Fungal Keratitis?
It is typically read by researchers, students, and practitioners in Materials Science.
- Author
- Liuqi Shi; Zhanrong Li; Zhen Liang; Junjie Zhang; Ruixing Liu; Dandan Chu; Lei Han; Lei Zhu; Jianliang Shen; Jingguo Li
- Publisher
- Elsevier BV
- Published
- 2022
- Language
- EN
- Field
- Materials Science (Physical Sciences)