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Can I read Antidepressant Efficacy in HIV-Seropositive Outpatients With Major Depressive Disorder: An Open Trial of Nefazodone on EtoBox?
Antidepressant Efficacy in HIV-Seropositive Outpatients With Major Depressive Disorder: An Open Trial of Nefazodone by Andrew J. Elliott; Joan Russo; Karen Bergam; Keith Claypoole; Karina K. Uldall; Peter P. Roy-Byrne is a Medicine article available to read on EtoBox.
What is Antidepressant Efficacy in HIV-Seropositive Outpatients With Major Depressive Disorder: An Open Trial of Nefazodone about?
Background: Treatment studies of major depression in patients who are seropositive for the human immunodeficiency virus (HIV) have shown comparable efficacy for both tricyclic antidepressants (TCAs) and selective serotonin reuptake inhibitors (SSRIs). Nefazodone appears to be more tolerable than TCAs and similar to SSRIs. This study examined the efficacy and tolerability of nefazodone in an open 12-week trial of HIV-seropositive outpatients with major depressive disorder. Method: Fifteen HIV-seropositive patients with DSM-IV major depressive disorder and a 21-item Hamilton Rating Scale for Depression (HAM-D) score of ≥ 18 were treated with open-label nefazodone for 12 weeks. Hamilton Rating Scale for Anxiety, HAM-D, Clinical Global Impressions scale, and Systematic Assessment for Treatment Emergent Events general inquiry (for safety and tolerability) scores were obtained at weeks 2, 4, 6, 8, and 12. Results: Of 15 patients receiving nefazodone, 4 discontinued treatment (1 for adverse effects). Of 11 patients who completed the trial, 8 (73%) were classified as full responders with a 50% reduction in HAM-D scores and final CGI score of 1 or 2, and 10 (91%) were classified as partial
Who reads Antidepressant Efficacy in HIV-Seropositive Outpatients With Major Depressive Disorder: An Open Trial of Nefazodone?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Andrew J. Elliott; Joan Russo; Karen Bergam; Keith Claypoole; Karina K. Uldall; Peter P. Roy-Byrne
- Publisher
- Physicians Postgraduate Press, Inc
- Published
- 1999
- Language
- EN
- Field
- Medicine (Health Sciences)