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Cognitive and psychiatric outcome 3 years after globus pallidus pars interna or subthalamic nucleus deep brain stimulation for Parkinson's disease by Judith A. Boel; Vincent J.J. Odekerken; Ben A. Schmand; Gert J. Geurtsen; Danielle C. Cath; Martijn Figee; Pepijn van den Munckhof; Rob J. de Haan; P. Richard Schuurman; Rob M.A. de Bie; Vincent J.J. Odekerken; Judith A. Boel; Teus van Laar; J.M.C. van Dijk; Arne Mosch; Carel F.E. Hoffmann; Peter C.G. Nijssen; T. van Asseldonk; Guus N. Beute; Jeroen P.P. van Vugt; Mathieu W.P.M. Lenders; M. Fiorella Contarino; Lo J. Bour; Gert J. Geurtsen; Pepijn van den Munckhof; Ben A. Schmand; Rob J. de Haan; P. Richard Schuurman; Rob M.A. de Bie is a Medicine article available to read on EtoBox.

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## Background: Effects on non-motor symptoms, mainly cognitive and psychiatric side effects, could influence the decision for either globus pallidus pars interna (gpi) or subthalamic nucleus (stn) deep brain stimulation (dbs) for patients with parkinson's disease (pd). ## Objective: 1) to compare cognitive and psychiatric outcomes 3 years after gpi dbs versus stn dbs, and 2) to report on occurrence of suicidal ideation, psychiatric diagnoses, social functioning, and marital satisfaction 3 years after dbs. ## Methods: Patients were randomized to receive gpi dbs (n = 65) or stn dbs (n = 63). standardized assessments were performed at baseline, 1 year, and 3 years. we used linear mixed model analyses to investigate between-group differences on the mattis dementia rating scale (mdrs), neuropsychological tests, and psychiatric questionnaires 3 years after dbs. ## Results: Eighty-seven patients (68%) completed at least one neuropsychological test after 3 years. no significant between-group differences were found on the mdrs (p = 0.61), neuropsychological tests (p-values between 0.17 and 0.87), and psychiatric questionnaires (p-values between 0.23 and 0.88) 3 years after dbs. the mini int

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Author

Judith A. Boel; Vincent J.J. Odekerken; Ben A. Schmand; Gert J. Geurtsen; Danielle C. Cath; Martijn Figee; Pepijn van den Munckhof; Rob J. de Haan; P. Richard Schuurman; Rob M.A. de Bie; Vincent J.J. Odekerken; Judith A. Boel; Teus van Laar; J.M.C. van Dijk; Arne Mosch; Carel F.E. Hoffmann; Peter C.G. Nijssen; T. van Asseldonk; Guus N. Beute; Jeroen P.P. van Vugt; Mathieu W.P.M. Lenders; M. Fiorella Contarino; Lo J. Bour; Gert J. Geurtsen; Pepijn van den Munckhof; Ben A. Schmand; Rob J. de Haan; P. Richard Schuurman; Rob M.A. de Bie

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 1353-8020)

Published

2016

Language

EN

Field

Medicine (Health Sciences)