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The Relationship Between Serum VCAM-1 and Alzheimer’s Disease in Patients with Type 2 Diabetes Mellitus by Zhang, Lingyun; Mao, Huawu is a Medicine article available to read on EtoBox.

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## Background Previous studies have reported that diabetes mellitus (DM) is a risk factor for Alzheimer’s disease (AD). Vascular cell adhesion molecule-1 (VCAM-1) plays an important role in the pathological process of atherosclerosis. The aim was to elucidate the relationship between serum VCAM-1 and early AD in DM patients. ## Methods Serum samples for VCAM-1 were tested in 208 DM patients. All included DM patients were followed up for a median of 36 months prospectively. The prognostic value of serum VCAM-1 for predicting AD events was analyzed by using Cox proportional hazard. ## Results Serum VCAM-1 was independently associated with AD history after adjusting for related confounding factors in patients with DM at baseline by using the logistic regression analysis (OR=1.861; 95% CI, 1.435–2.539; __P__~trend~=0.020). The Cox proportional hazard model suggested that VCAM-1 was a prognostic factor for AD events in the DM patients (HR=2.728; 95% CI, 1.785–5.439; __P__~trend~<0.001). Stratified analysis showed that the significant association between AD event and serum VCAM-1 in DM patients was not affective by CVD history. ## Conclusion Our results showed that higher VCAM-1 levels w

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Author

Zhang, Lingyun; Mao, Huawu

Publisher

Dove Press Ltd.; Dove Medical Press; Dove Medical Press Ltd.; Informa UK Limited (ISSN 1178-7007)

Published

2020

Language

EN

Field

Medicine (Health Sciences)