About this document
Muscarinic Blockade in Antipsychotics by silvana is a document available to read on EtoBox.
1) Conventional antipsychotics block dopamine D2 receptors and muscarinic M1-cholinergic receptors. Blocking the muscarinic receptors helps reduce extrapyramidal side effects caused by dopamine receptor blockade. 2) Dopamine normally inhibits acetylcholine release in the nigrostriatal pathway. When dopamine is blocked by antipsychotics, acetylcholine becomes overly active, causing extrapyramidal symptoms. 3) Anticholinergic effects of some antipsychotics help compensate for this by blocking the excess a
- Author
- silvana
- Language
- EN