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Glymphatic System Dysfunction in Patients with Juvenile Myoclonic Epilepsy by Ho-Joon Lee; Dong Ah Lee; Kyong Jin Shin; Kang Min Park is a Medicine article available to read on EtoBox.

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Objective The glymphatic system is a glial cell-dependent waste clearance pathway in the brain that is essential for the maintenance of brain homeostasis. In this study, we evaluated glymphatic system function in patients with juvenile myoclonic epilepsy (JME) compared with healthy controls. Methods Patients with JME and healthy controls were retrospectively enrolled in this study. All the participants underwent brain diffusion tensor imaging (DTI). The "DTI-analysis along the perivascular space (ALPS)"-index was calculated to evaluate the glymphatic system function of the participants. The ALPS-indices of the patients with JME were compared with those of the healthy controls. In addition, the correlations between ALPS-index and the clinical characteristics of the patients with JME were analyzed to validate changes in glymphatic system function. Results A total of 39 patients with JME and 38 healthy controls were enrolled in this study. The mean ALPS-index of the patients with JME was significantly lower than that of the healthy controls (1.541 vs. 1.653, p = 0.041). ALPS-index was negatively correlated with age in patients with JME (r = -0.375, p = 0.018). However, ALPS-index was

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Author

Ho-Joon Lee; Dong Ah Lee; Kyong Jin Shin; Kang Min Park

Publisher

Springer Science and Business Media LLC

Published

2021

Language

EN

Field

Medicine (Health Sciences)