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Pharmacokinetics in Routine Haemophilia Clinical Practice: Rationale and Modalities—a Practical Review by Cedric Hermans; Gerry Dolan is a Medicine article available to read on EtoBox.

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Prophylactic therapy with exogenous clotting factor concentrates in haemophilia A and B aims to achieve levels of circulating FVIII or FIX that are adequate for the prevention or reduction of spontaneous joint bleeding. Historically, a minimum trough level of at least 1% of the normal levels of circulating clotting factor has been targeted using standardised protocols. However, clearance of clotting factor varies between products and patients, and other pharmacokinetic (PK) parameters such as the frequency and magnitude of peaks may be important for ensuring optimal coverage. Thus, it is increasingly recognised that an individualised, PK-based approach to prophylaxis is necessary to achieve optimal protection. This review focuses on the clinical implications of using PK-guided, individualised prophylaxis in haemophilia to improve patient outcomes and considers practical methods of establishing patients’ PK parameters. The most useful PK parameters will depend on the aim of the specific treatment (e.g. preventing activity-related and traumatic bleeds or addressing subclinical bleeding). In clinical practice, lengthy and frequent post-infusion sampling for PK analysis is costly and a

Who reads Pharmacokinetics in Routine Haemophilia Clinical Practice: Rationale and Modalities—a Practical Review?

Author

Cedric Hermans; Gerry Dolan

Publisher

SAGE Publications (ISSN 2040-6207)

Published

2020

Language

EN

Field

Medicine (Health Sciences)