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Hepatocyte Growth Factor/scatter Factor Expressed in Follicular Papilla Cells Stimulates Human Hair Growth in Vitro by Shin Shimaoka; Ryoji Tsuboi; Toshimasa Jindo; Ryusuke Imai; Kenji Takamori; Jeffrey S. Rubin; Hideoki Ogawa is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Hepatocyte Growth Factor/scatter Factor Expressed in Follicular Papilla Cells Stimulates Human Hair Growth in Vitro about?
Hepatocyte growth factor/scatter factor (HGF/SF) is a multifunctional polypeptide which acts as mitogen, motogen, or morphogen. In this study, we examined the effect of HGF/SF on human hair growth using organ and cell culture systems. HGF/SF was found to stimulate hair length and DNA synthesis in hair follicles at increasing concentrations up to 10 ng/ml ( P < 0.05 and P < 0.01, respectively). HGF/SF stimulated ['Hlthymidine incorporation by hair bulb-derived keratinocytes with the strongest response at 30 ng/ml of HGF/SF ( P < 0.05). Cultured follicular papilla cells secreted HGF/SF, measured by an enzyme-linked immunoassay, in response to interleukin 1 -a (IL1 -a, 10 ng/ml), tumor necrosis factor-a (TNF-a, 10 ng/ml), or tetradecanoylphorbolacetate (1 00 nM) at levels ranging from 0.2 to 0.3 ndmg protein/48 h. HGF/SF mRNA expressions, measured by the reverse transcription-polymerase chain reaction, were detected in follicular papilla cells, and were also stimulated by the three reagents. Transforming growth factor-p (1 0 ng/ml) suppressed both protein and mRNA levels. These results suggest that hair follicle elongation induced by HGF/SF in organ culture occurs partly due to the mi
Who reads Hepatocyte Growth Factor/scatter Factor Expressed in Follicular Papilla Cells Stimulates Human Hair Growth in Vitro?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Shin Shimaoka; Ryoji Tsuboi; Toshimasa Jindo; Ryusuke Imai; Kenji Takamori; Jeffrey S. Rubin; Hideoki Ogawa
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0021-9541)
- Published
- 1995
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)