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Effects of Humoral Modulators and Naloxone on Morphine-induced Changes in the Spontaneous Locomotor Activity of the Rat by Tetsuo Oka; Eikichi Hosoya is a Neuroscience article available to read on EtoBox.

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The s.c. administration of 20 mg/kg of morphine-HC1 produced a decrease in the spontaneous locomotor activity (SLMA) of rats. The decrease in SLMA was significantly antagonized by p-chlorophenylalanine (p-CPA). When rats pretreated with p-CPA were given 5-hydroxytryptophan before morphine injection, the marked sedative response to morphine was restored, suggesting that the morphineinduced decrease in SLMA of rats may depend on the release of 5-hydroxytryptamine by morphine. By contrast, the s.c. administration of 5 mg/kg of morphine-HC1 produced a significant increase in SLMA of rats. The magnitude of the increase was reduced by atropine, scopolamine or c~-methyl-p-tyrosine. It appears that both adrenergic and cholinergic mechanisms participate in the increase in SLMA of rats induced by morphine. Both the increase in SLMA produced by 5 mg/kg of morphine and the decrease in SLMA induced by 20 mg/kg of morphine were completely antagonized by the s.c. administration of naloxone-HC1, 0.0625 and 0.25 mg/kg, respectively. Thus, it appears that the receptor with which morphine interacts to produce stimulation is chemically identical with or very similar to the receptor with which morphine

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Author

Tetsuo Oka; Eikichi Hosoya

Publisher

Springer; Springer-Verlag; Springer Verlag; Springer Science and Business Media LLC (ISSN 0033-3158)

Published

1976

Language

EN

Field

Neuroscience (Life Sciences)