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What is Pneumococcal Vaccine Manufacturing Process about?

This document describes the manufacturing process for 21 pneumococcal polysaccharide serotypes used as an intermediate in a 21-valent conjugate vaccine. The process involves fermentation, inactivation, clarification, ultrafiltration, polishing, and recovery stages. Some parameters vary by serotype to accommodate differences in strains, process properties, and manufacturing scale/facility. The polysaccharides are produced through large-scale fermentation and purified using standardized unit operations to gen

Author

71403971

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EN