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Can I read Association of BDNF , HTR2A , TPH1 , SLC6A4 , and COMT polymorphisms with tDCS and escitalopram efficacy: ancillary analysis of a double-blind, placebo-controlled trial on EtoBox?
Association of BDNF , HTR2A , TPH1 , SLC6A4 , and COMT polymorphisms with tDCS and escitalopram efficacy: ancillary analysis of a double-blind, placebo-controlled trial by Andre R. Brunoni; Angel Carracedo; Olalla M. Amigo; Ana L. Pellicer; Leda Talib; Andre F. Carvalho; Paulo A. Lotufo; Isabela M. Benseñor; Wagner Gattaz; Carolina Cappi is a Psychology article available to read on EtoBox.
What is Association of BDNF , HTR2A , TPH1 , SLC6A4 , and COMT polymorphisms with tDCS and escitalopram efficacy: ancillary analysis of a double-blind, placebo-controlled trial about?
## Objective: We investigated whether single nucleotide polymorphisms (SNPs) associated with neuroplasticity and activity of monoamine neurotransmitters, such as the brain-derived neurotrophic factor (__BDNF__, rs6265), the serotonin transporter (__SLC6A4__, rs25531), the tryptophan hydroxylase 1 (__TPH1__, rs1800532), the 5-hydroxytryptamine receptor 2A (__HTR2A__, rs6311, rs6313, rs7997012), and the catechol-O-methyltransferase (__COMT,__ rs4680) genes, are associated with efficacy of transcranial direct current stimulation (tDCS) in major depression. ## Methods: Data from the Escitalopram vs. Electrical Current Therapy for Treating Depression Clinical Study (ELECT-TDCS) were used. Participants were antidepressant-free at baseline and presented with an acute, moderate-to-severe unipolar depressive episode. They were randomized to receive escitalopram/tDCS-sham (n=75), tDCS/placebo-pill (n=75), or placebo-pill/sham-tDCS (n=45). General linear models assessed the interaction between treatment group and allele-wise carriers. Additional analyses were performed for each group and each genotype separately. ## Results: Pairwise group comparisons (tDCS vs. placebo, tDCS vs. escitalopram,
Who reads Association of BDNF , HTR2A , TPH1 , SLC6A4 , and COMT polymorphisms with tDCS and escitalopram efficacy: ancillary analysis of a double-blind, placebo-controlled trial?
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- Author
- Andre R. Brunoni; Angel Carracedo; Olalla M. Amigo; Ana L. Pellicer; Leda Talib; Andre F. Carvalho; Paulo A. Lotufo; Isabela M. Benseñor; Wagner Gattaz; Carolina Cappi
- Publisher
- EDITORA SCIENTIFIC
- Published
- 2019
- Language
- EN
- Field
- Psychology (Social Sciences)